Table 3.

Spearman correlation coefficient between ENPP2 CG methylation and mRNA expression for each of our clinical endpoints. CGs showing significant correlations are depicted (|rho| >= 0.40, FDR < 5 × 10⁻²).

BrCa vs. Normal
Tissue	CG	Gene Region	Rho	FDR	Correlation
BrCa	cg02534163	First Exon	−0.40	1.18 × 10−12	Negative
	cg06998282	TSS1500	−0.42	1.53 × 10−13	Negative
	cg14409958	TSS1500	−0.42	2.10 × 10−13	Negative
Normal	cg09444531	Body	0.62	4.77 × 10−06	Positive
	cg23725583	Body	−0.70	3.02 × 10−11	Negative
	cg07236691	Body	−0.55	1.27 × 10−08	Negative
	cg14409958	TSS1500	−0.52	9.53 × 10−07	Negative
Stage I BrCa vs. Normal
Stage I	cg02534163	First Exon	−0.46	1.54 × 10−06	Negative
	cg04452959	TSS200	−0.44	3.74 × 10−06	Negative
	cg14409958	TSS1500	−0.64	3.29 × 10−13	Negative
	cg02156680	TSS1500	−0.42	1.28 × 10−05	Negative
	cg06998282	TSS1500	−0.63	6.04 × 10−13	Negative
Normal	cg09444531	Body	0.64	3.25 × 10−08	Positive
	cg23725583	Body	−0.66	1.36 × 10−08	Negative
	cg07236691	Body	−0.53	1.40 × 10−05	Negative
	cg14409958	TSS1500	−0.51	4.25 × 10−05	Negative
Early vs. Advanced BrCa
Early	cg02534163	First Exon	−0.42	2.56 × 10−23	Negative
	cg06998282	TSS1500	−0.47	4.588 × 10−29	Negative
	cg14409958	TSS1500	−0.46	5.37 × 10−28	Negative
Advanced	cg02534163	First Exon	−0.43	1.23 × 10−09	Negative
	cg04452959	TSS200	−0.41	5.47 × 10−09	Negative
	cg14409958	TSS1500	−0.48	4.72 × 10−12	Negative
	cg06998282	TSS1500	−0.49	4.18 × 10−12	Negative

Abbreviations: FDR: false discovery rate, TSS: Transcription Start Site.