FIG. 9.

Time-kill curves of polygodial comparing wild-type S. cerevisiae ATCC 7754 to petite mutants, which are respiration deficient, in ME medium. Control cultures of each strain were not significantly different from the wild type (●). Polygodial at 3.13 μg/ml was exposed to the wild type (○) and to strains which were collected from another time-kill experiment as phenotypically large (▿), medium (□), small (◊), and very small (▵) strains. The [rho⁰] mutant is represented by dashed lines (+).