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. 2022 Mar 30;23(7):3818. doi: 10.3390/ijms23073818

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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EGFR mutations in relation to EGFR copy number (A), mRNA (B), protein (C), and genome-wide aneuploidy (D) levels and overall mutational burden (E) in HNSCC patients curated in the cBioPortal for Cancer Genomics. EGFR mutations rarely co-segregate with EGFR amplifications (A) and show ranges of EGFR mRNA (B) and protein (C) expression comparable to their non-amplified counterparts. EGFR mutated tumors show a range of chromosomal aneuploidy scores (D) similar to non-mutated tumors, but demonstrate a significantly lower overall mutational burden (E). EGFR genomic, and aneuploidy, and mutational count data were visualized, analyzed, and downloaded from the cBioPortal for Cancer Genomics (https://www.cbioportal.org; accessed on 19 March 2022 [22,23]).