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. 2022 Mar 23;23(7):3467. doi: 10.3390/ijms23073467

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Topical application of ERK inhibitor improves the histological changes of mite antigen-induced AD in mice. Histological appearance (hematoxylin-eosin staining) of skin lesions of control (A), AD (B), and AD + U0126 (C) groups on day 7. Scale bar: 50 μm. (D) Number of total inflammatory cells in dermis on the dorsal skin of mice. Measurements of epidermal thickness and epidermal + dermal thickness ** p < 0.01, *** p < 0.001 one-way analysis of variance followed by Bonferroni’s multiple comparison test. (E) Immunohistochemical staining for intraepidermal p-ERK expression of skin lesions of AD and AD + U0126 groups. Scale bar: 100 μm., *** p < 0.001 Student’s unpaired two-tailed t-test on each day. All data are presented as mean ± S.E.M. (n = 3 control group, n = 8 AD group, n = 8 AD + U0126 group).