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. 2022 Mar 25;23(7):3590. doi: 10.3390/ijms23073590

Figure 15.

Figure 15

Scheme demonstrating the mechanism of IGT according to the KARM. (I). Formation of the cargo ribbon. (A) Arrival of two cargo domains. (B) Arrival of new domains and their fusion, leading to the parallel ribbon. (C) Budding of the cargo domains from the Golgi cisternae. (II). (A) The asymmetric KARM (carrier maturation) poses that a cargo domain (sphere in the upper-left image fuses with the cisternal rims containing several pores. This is shown in (B,C). (D,E) The cargo domain fuses with the distal cisterna with the tubule. (F) Break of the tubules within the zone where pores were situated. (G) Fission of the tubule connecting the cargo domain and the proximal cisterna. (H,I) Arrival of the trans-Golgi network, its fusion with the cargo domain, and the consecutive fission of the tubule connecting the cargo domain and the distal cisterna.