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. 2022 Mar 24;23(7):3529. doi: 10.3390/ijms23073529

Figure 1.

Figure 1

Balance of positive and negative signals tuning the immune response. Images created using RCSB PDB (www.rcsb.org accessed on 1 February 2022) and the Mol* application [10]. The TCR complex structure is 6JXR [11], the CTLA-4 partial dimeric structure is 3OSK [12], the ZAP70 structure is 4K2R [13], the SHP-2 structure is 2SHP [14], the SHIP-1 partial structure is 6XY7, the PD-1 extracellular domain is 3RRQ, and the CD28 extracellular is 6O8D (available in PDB, to be published). LCK, PLCΥ1, and DGKA models are from AlphaFold [15].