Table 3.

Oxo heterocyclic small-molecule RAS inhibitors.

Cancer Type	Compound Name	Structure	Major Pharmacophore(s)	Biomolecular Target (M/A)	Reference
Lung cancer	NHTD		Tetrahydrodibenzofuran, 2,4-Dihydroxybenzohydrazide	Inhibits tumor progression, decreasing CRAF, ERK, and AKT phosphorylation	[102]
Unknown	PD98059		Chromenone	MEK inhibitor	[128]
Colorectal cancer	Wortmannin		Furoindenoisochromene	Suppresses upregulation of PI3K	[129]