Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Metabolic activity and mitophagy. Decrease in energetic supply inhibits mTOR activity, which enhances autophagy. The energetic starvation leads to the loss of mitochondria membrane potential, associated to ROS overproduction. This condition activates PTEN-induced putative kinase 1 (PINK1) and the E3 ligase parkin (PARK2), which is able to ubiquitylate mitochondrial outer membrane proteins, providing recognition signals to the active autophagy machinery.
