Table 1.
Main genes involved in autophagosome regulation machinery.
| Functional Step | Gene | Function |
|---|---|---|
| Induction of autophagy | mTOR | Negative regulator of autophagy |
| ULK1 | Part of the complex ULK1 kinase | |
| ATG13 | ||
| RB1CC1 | ||
| Autophagosome formation | ATG 2 | Components of ATG9-WIPI complex and Vps34-beclin1 class III PI3-kinase complex |
| ATG 9 | ||
| WIPI1/2 | ||
| PI3KC3 | ||
| PI3KR4 | ||
| BECN1 | ||
| ATG14 | ||
| ATG12 | ||
| ATG5 | ||
| ATG7 | ||
| Autophagosome maturation | ATG16 | LC3/ATG8 conjugation |
| ATG10 | ||
| CAMKK2 | ||
| MAP1LC3B | ||
| ATG8 | ||
| Autophagosome/lysosome fusion and degradation | ATG3 | Ubiquitin-like conjugation systems |
| ATG4 | ||
| TFEB | Regulation of lysosomal genes and fusion with autophagosome | |
| RAB7 |