Table 2.

Summary of PCa drugs interfering with autophagic activity.

Drug	Mechanism of Action	Effect on Autophagy
Abiraterone	Blocking testosterone biosynthesis (CYP17)	Triggering autophagy and mitophagy
Enzalutamide	Blocking testosterone binding to AR	Triggering autophagy via mTOR inhibition
	Preventing AR nuclear translocation
Apalutamide	Blocking testosterone binding to AR	Triggering autophagy
	Preventing AR nuclear translocation
Docetaxel	Inhibition of microtubular depolymerization	Triggering autophagy via upregulation FOXM1 expression
	Phosphorylation and inactivation of the bcl-2 protein