Table 3.

The ten best common feature-derived hypothetical pharmacophores constructed on the basis of four clinically approved EGFR inhibitors.

Pharmacophore Hypothesis	Rank	Direct Hit	Partial Hit	Max Hit	Features
Pharm1	54.25	1101	0010	6	RRHHAA
Pharm2	53.04	1111	0000	6	HHHDAA
Pharm3	52.64	1101	0010	6	RRHHAA
Pharm4	52.48	1111	0000	5	RRHAA
Pharm5	52.32	1101	0010	6	RRHHAA
Pharm6	52.32	1101	0010	6	RRHHAA
Pharm7	52.25	1101	0010	6	RRHHAA
Pharm8	52.25	1101	0010	6	RRHHAA
Pharm9	52.20	1111	0000	5	RRHAA
Pharm10	52.20	1111	0000	5	RRHAA

Features: A, hydrogen bond acceptor; D, hydrogen bond donor; H, hydrophobic area; and R, ring aromatic.