TABLE 2.
Hepatic WHV replicative intermediates of woodchucks with chronic WHV infection treated with HDP-P-ACVa
| Treatment and time | Hepatic WHV RI (mean pg/μg of cell DNA ± SD)b |
|---|---|
| Expt 1 | |
| Placebo | |
| Time zero | 1,388 ± 485 (4) |
| Wk 4 | 1,420 ± 369 (4) |
| Wk 12 | 1,440 ± 429 (4) |
| ACV (20 mg/kg b.i.d.) | |
| Time zero | 1,488 ± 498 (4) |
| Wk 4 | 1,250 ± 206 (4) |
| Wk 12 | 1,455 ± 497 (4) |
| HDP-P-ACV (10 mg/kg b.i.d.) | |
| Time zero | 1,613 ± 477 (4) |
| Wk 4 | 733 ± 215 (4)* |
| Wk 12 | 1,450 ± 320 (4) |
| HDP-P-ACV (20 mg/kg b.i.d.) | |
| Time zero | 1,775 ± 311 (4) |
| Wk 4 | 1,293 ± 360 (4) |
| Wk 12 | 1,273 ± 329 (4) |
| Expt 2 | |
| Placebo | |
| Time zero | 998 ± 552 (4) |
| Wk 4 | 1,443 ± 412 (4) |
| Wk 12 | 1,175 ± 83 (4) |
| HDP-P-ACV (5 mg/kg b.i.d.) | |
| Time zero | 1,450 ± 320 (4) |
| Wk 4 | 1,208 ± 301 (4) |
| Wk 12 | 1,350 ± 206 (4) |
| HDP-P-ACV (30 mg/kg q.d.) | |
| Time zero | 1,650 ± 320 (4) |
| Wk 4 | 1,525 ± 415 (4) |
| Wk 12 | 1,433 ± 236 (3) |
a
Woodchucks were treated with HDP-P-ACV for 4 weeks or were left untreated. Measurements were taken at time zero, at the end of treatment, and during posttreatment follow-up.
b
Number of replicates is given in parentheses. Asterisk, P < 0.05 versus value at time zero.