Table 2.
Twenty-one pathways showed an interaction with the top 10 miRNAs associated with a Hamilton Rating Scale for Depression score reduction after 2 weeks of SSRI treatment. Caption: The 21 pathways that were significantly associated with 10 miRNAs (miR-483-5p, miR-3151-5p, miR-7109-5p, miR-6807-5p, miR-30c-1-3p, miR-6769a-3p, miR-7111-3p, miR-6796-3p, miR-1249-5p, miR-4534). p-values were obtained following conservative stats analysis based on the probability of a jackknifing test and FDR correction.
| Pathway | Database | p-Value | #Genes | #miRNAs |
|---|---|---|---|---|
| TGF-beta signaling pathway | microT-CDS/Tarbase | 0.006/0.036 | 21/6 | 8/1 |
| Proteoglycans in cancer | microT-CDS | <0.001 | 41 | 9 |
| Long-term depression | TargetScan | 0.002 | 13 | 5 |
| Glutamatergic synapse | microT-CDS | 0.006 | 26 | 8 |
| Thyroid hormone signaling pathway | microT-CDS | 0.006 | 26 | 9 |
| Amphetamine addiction | microT-CDS | 0.024 | 16 | 7 |
| Morphine addiction | microT-CDS | 0.025 | 22 | 8 |
| Endocrine and other factor-regulated calcium reabsorption | microT-CDS | 0.027 | 13 | 6 |
| Calcium signaling pathway | microT-CDS | 0.027 | 36 | 8 |
| Hippo signaling pathway | microT-CDS | 0.027 | 28 | 8 |
| Signaling pathways regulating pluripotency of stem cells | microT-CDS | 0.027 | 27 | 9 |
| Dilated cardiomyopathy | microT-CDS | 0.027 | 22 | 9 |
| MAPK signaling pathway | microT-CDS | 0.028 | 49 | 9 |
| Circadian entrainment | microT-CDS | 0.028 | 24 | 9 |
| Colorectal cancer | microT-CDS | 0.038 | 13 | 5 |
| ErbB signaling pathway | microT-CDS | 0.038 | 17 | 7 |
| ECM-receptor interaction | microT-CDS | 0.038 | 16 | 7 |
| Axon guidance | microT-CDS | 0.038 | 25 | 8 |
| Cytokine-cytokine receptor interaction | microT-CDS | 0.038 | 37 | 9 |
| Endocytosis | microT-CDS | 0.038 | 37 | 10 |
| Focal adhesion | microT-CDS | 0.049 | 40 | 10 |