Figure 5.

Apoptosis induced by SeCoV infection and modulatory mechanisms. Schematic diagram showing the signaling pathways of intrinsic and extrinsic apoptosis and the modulatory mechanisms during SeCoV infection. The yellow ovals are proapoptotic proteins, whereas the blue ovals are antiapoptotic proteins. The viral or viral components involved in the modulation of apoptosis are shown in bold red in the figure. Abbreviations: FADD, Fas-associated via death domain; BID, BH3-interacting domain death agonist; BAX, Bcl2-associated X; Mcl1, myeloid cell leukemia 1; Mcl1, myeloid cell leukemia 1; and APAF1, apoptotic peptidase-activating factor 1.