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. 2022 Apr 6;23(7):4067. doi: 10.3390/ijms23074067

Figure 1.

Figure 1

(A). Luteolin treatment of HeLa cells at 10 and 20 µM for 48 h demonstrated profound decrease in percentage methylation in 5′ CpG promoter regions of TSGs, as compared with the untreated controls, in a dose-dependent manner (* represents that data is statistically significant with p ≤ 0.05). (B). Luteolin decreased global DNA methylation in HeLa cells. The data are presented as mean of three independent experiments ± SD (* represents that data is statistically significant with p ≤ 0.05). (C). Luteolin decreased DNMT activity in HeLa cells in a concentration-dependent manner. The activity of the treated was compared with the untreated, and the values plotted are the mean of three experiments ± SD (* represents that data is statistically significant with p ≤ 0.05).