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. 2022 Mar 31;23(7):3887. doi: 10.3390/ijms23073887

Figure 5.

Figure 5

IDH1/2 mutant converts α-ketoglutarate into 2-hydroxyglutarate, which interacts with α-KG-dependent enzymes and leads to DNA hypermethylation. IDH1/2 inhibitors prevent α-KG production and restore a normal DNA methylation profile.