Figure 9.

GLOBLE predictions of clonogenic survival upon different levels of auxin-induced CTCF depletion in mESC-AID-CTCF cells, in comparison to the experimental data. The reference condition (0 µM auxin) is depicted as a full thin black curve. Bold dashed black lines indicate the model predictions for the experimentally determined CTCF depletion levels, whose experimental data from four biological replicates is shown as colored fit lines (curve fit weighted by $\frac{1}{relative erro{r}^2}$) and dots (mean) for comparison (whiskers = error bars). (a) Predictions modeled based on the standard 2 Mbp domain size. (b,c) Predictions modeled based on a domain size of 5 (b) and 10 Mbp (c).