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. 2022 Mar 31;23(7):3896. doi: 10.3390/ijms23073896

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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GLOBLE predictions of radiation sensitivity analyzing the impact of CTCF depletion on differentially sized control chromatin domains. As an indicator of the impact, the ratios of D10 (the dose required to achieve 10% survival) under control conditions to the D10 after CTCF depletion are used. CTCF depletion has the most significant impact for control domain sizes below approximately 2 Mbp for all 3 cell lines, whereas towards larger control domain sizes, the impact is reduced. The black dotted line indicates the reference value, corresponding to CTCF depletion having no impact.