Table 1.
Characteristics of patients with liver cirrhosis.
| Variable | Total (n = 99) | Chronic Hepatitis (n = 15) | Liver Cirrhosis | ||
|---|---|---|---|---|---|
| Child–Pugh Class A (n = 25) | Child–Pugh Class B (n = 23) | Child–Pugh Class C (n = 36) | |||
| Age (year) | 67 (60–74) | 60 (51–67) | 72 (68–76) * | 64 (58–68) | 69 (61–74) * |
| Sex (male/female) | 63/36 | 9/6 | 19/6 | 14/9 | 21/15 |
| Etiology (HBV/HCV/Alcohol/NASH/PBC/unknown) | 12/67/10/6/3/1 | 0/15/0/0/0/0 | 1/18/4/2/0/0 | 6/15/1/1/0/0 | 5/19/5/3/3/1 |
| Albumin (g/dL) | 3.2 (2.8–3.8) | 4.2 (3.9–4.5) | 3.4 (3.1–4.1) * | 3.2 (2.9–3.4) ** | 2.7 (2.5–3.0) *** |
| Aspartate aminotransferase (IU/L) | 52 (38–76) | 39 (31–48) | 52 (38–64) | 56 (41–89) | 63 (38–85) |
| Alanine aminotransferase (IU/L) | 42 (26–58) | 50 (35–61) | 38 (27–55) | 45 (30–60) | 32 (23–53) |
| Prothrombin time (%) | 75 (53–89) | 98 (94–105) | 83 (80–92) * | 71 (64–84) ** | 50 (38–57) *** |
| Blood urea nitrogen (mg/dL) | 17 (12–26) | 13 (10–15) | 16 (10–20) | 16 (14–22) * | 26 (16–45) *** |
| Creatinine (mg/dL) | 0.8 (0.7–1.1) | 0.8 (0.6–0.8) | 0.8 (0.7–0.9) | 0.7 (0.6–1.0) | 1.0 (0.7–1.5) *, ** |
| Total bilirubin (mg/dL) | 1.6 (0.8–2.6) | 0.6 (0.5–1.4) | 1.0 (0.7–1.3) * | 1.6 (0.9–1.9) ** | 3.4 (2.3–5.3) *** |
| White blood cell count (/mm3) | 4400 (2975–6200) | 5200 (3700–6150) | 4400 (2900–5500) | 3750 (2575–5100) | 5250 (3300–8175) |
| Hemoglobin (g/dL) | 11.4 (9.6–12.8) | 14.0 (12.1–15.5) | 12.0 (11.1–12.8) * | 12.2 (10.9–13.0) | 9.0 (7.7–10.9) *** |
| Platelet count (×104/mm3) | 7.7 (5.9–11.0) | 14.2 (9.7–17.2) | 9.2 (7.6–12.7) * | 6.4 (5.2–8.3) ** | 6.4 (4.8–7.7) ** |
| Ascites (none/mild to moderate/severe) | 62/12/25 | 15/0/0 | 25/0/0 | 14/7/2 ** | 8/5/23 *** |
| Hepatorenal syndrome (with/without) | 9/90 | 0/15 | 0/25 | 1/22 | 8/28 *** |
| Encephalopathy (with/without) | 37/62 | 0/15 | 0/25 | 7/16 ** | 30/6 *** |
| Esophageal varices (with/without) | 65/34 | 0/15 | 16/9 * | 19/4 * | 30/6 * |
| Hepatocellular carcinoma (with/without) | 46/53 | 1/14 | 17/8 * | 12/11 * | 16/20 * |
* p < 0.05 between chronic hepatitis and Child–Pugh class A, B, or C; ** p < 0.05 between Child–Pugh classes A and B or C; *** p < 0.05 between Child–Pugh classes B and C; data are expressed as medians (interquartile ranges); HBV, hepatitis B virus; HCV, hepatitis C virus; NASH, nonalcoholic steatohepatitis; PBC, primary biliary cholangitis.