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. 2022 Apr 6;23(7):4037. doi: 10.3390/ijms23074037

Figure 2.

Figure 2

In HCC, miR-424-5p can be regulated by upstream pathways and regulate downstream pathways. (i) XIST can increase the expression of miR-424-5p, which inhibits ATG14, inhibiting HCC proliferation and migration. (ii) The decrease in DLX6-AS1 can target miR-424-5p to inhibit the expression of WEE1, which inhibits HCC proliferation and migration. (iii) PVT1 inhibits the expression of miR-424-5p by regulating the p53 signaling pathway to promote HCC proliferation. (iv) LncRNAs, including MYLK-AS1, CDKN2B-AS1, and CAS9, can affect the expression of miR-424-5p to regulate HCC progression.