Table 1.

Role of miR-424-5p in various cancers.

Type of Cancer	Effect of mir-424-5p	Mechanisms	Reference
Hepatocellular carcinoma (HCC)	Tumor suppressor	Inhibit ATG14, WEE1, activate E2F7	[21,22]
Intrahepatic cholangiocarcinoma (ICC)	Tumor suppressor	Regulate ARK5, inhibit mTOR phosphorylation	[23]
Ovarian cancer	Tumor suppressor	Inhibit ACSL4, KIF23, activate CCNE1J, MIEF2	[24,25]
Cervical cancer	Tumor suppressor	Activate KDM5B-Notch	[26]
Malignant tumors of the nervous system	Tumor suppressor	Target BFAR and ALK receptor directly, increase βFGF	[27]
Breast cancer	Tumor suppressor	Target PD-L1, regulate PTEN/PI3K/AKT/mTOR	[28]
Non-small cell carcinoma (NSCLC)	Tumor suppressor	Inhibit CARM1	[29]
Osteosarcoma	Tumor suppressor	Target VEGFA, inhibit angiogenesis	[30]
Nasopharyngeal carcinoma	Tumor suppressor	Inhibit AKT3	[31]
Pancreatic cancer	Oncogene	Inhibit SOC6 to regulate ERK1/2	[32]
Thyroid cancer	Oncogene	Target WWC1, SAV1, LSAT2 to inhibit Hippo	[33]
Gastric (stomach cancer)	Oncogene	Target Smad3 to regulate TGF-β	[34]
Laryngeal squamous-cell Carcinoma	Tumor suppressor	Inhibit CADM1	[35]
Oral squamous-cell Carcinoma	Tumor suppressor	Activate IL-8 to inhibit SOCS2; activate SCAI	[36]
Esophageal squamous-cell Carcinoma	Evidence for both	Oncogene: target SIRT4;Tumor suppressor: inhibit Smad7	[37,38]
Cervical squamous-cell carcinoma	oncogene	Target CCND1, CCNE1, WEE1 to regulate cell cycle	[39]
Colorectal cancer	Evidence for both	Oncogene: target SCN4B;Tumor suppressor: inhibit OTX1	[40,41]