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. 2022 Apr 6;23(7):4050. doi: 10.3390/ijms23074050

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Neutralization activities of entry inhibitors against pseudoviruses carrying spike proteins of major SARS-CoV-2 variants. SmBiT-ACE2 cells were infected with SARS-CoV-2-pseudotyped viruses mixed with indicated DMSO, Dolutegravir, or Etravirine for 6 h and then removed from culture. Following 24 h post infection, bioluminescence signals of infected cells were detected by a bioluminescence imager and bioluminescent plate reader. Representative bioluminescence images of pseudotyped virus infection are shown. EC50 values of indicated entry drugs against different variants are shown.