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. 2022 Mar 22;11(7):1752. doi: 10.3390/jcm11071752

Table 3.

Comparison of complications, mortality, and readmissions between pre-COVID and COVID period by Major Diagnostic Categories (MDC). CI: confidence interval. RR: risk ratio. * p value < 0.05. ** Others category includes MDC with <100 episodes.

Complications In-Hospital Mortality Readmissions
MDC Pre-COVID-19 Period
N (%)
COVID-19 Period
N (%)
RR (95% CI) Pre-COVID-19 Period
N (%)
COVID-19 Period
N (%)
RR (95% CI) Pre-COVID-19 Period
N (%)
COVID-19 Period
N (%)
RR (95% CI)
Total 600 (1.84%) 265 (2.23%) 1.21 (1.05;1.40) * 1337 (4.10%) 529 (4.45%) 1.09 (0.98;1.20) 1371 (4.21%) 381 (3.21%) 0.76 (0.68;0.85) *
Diseases and disorders of the respiratory system 58 (0.99%) 12 (0.67%) 0.67 (0.36;1.25) 384 (6.58%) 115 (6.42%) 0.98 (0.80;1.19) 517 (8.85%) 104 (5.81%) 0.66 (0.53;0.80) *
Diseases and disorders of the circulatory system 83 (1.49%) 45 (2.11%) 1.42 (0.99;2.04) 237 (4.25%) 79 (3.71%) 0.87 (0.68;1.12) 255 (4.57%) 79 (3.71%) 0.81 (0.63;1.04)
Diseases and disorders of the digestive system 119 (3.02%) 56 (3.91%) 1.30 (0.95;1.77) 116 (2.94%) 61 (4.26%) 1.45 (1.07;1.96) * 152 (3.85%) 27 (1.89%) 0.49 (0.33;0.73) *
Diseases and disorders of the nervous system 80 (3.49%) 39 (4.10%) 1.17 (0.81;1.71) 163 (7.11%) 74 (7.77%) 1.09 (0.84;1.42) 38 (1.66%) 11 (1.16%) 0.70 (0.36;1.36)
Diseases and disorders of the musculoskeletal system and connective tissue 60 (2.33%) 33 (3.86%) 1.66 (1.09;2.51) * 61 (2.37%) 28 (3.28%) 1.38 (0.89;2.15) 29 (1.13%) 16 (1.87%) 1.66 (0.91;3.04)
Kidney and urinary tract diseases and disorders 70 (2.72%) 18 (1.90%) 0.70 (0.42;1.17) 48 (1.86%) 31 (3.28%) 1.76 (1.13;2.74) * 107 (4.16%) 37 (3.91%) 0.94 (0.65;1.36)
Mental illnesses or disorders 1 (0.04%) 3 (0.33%) 7.35 (0.77;70.56) 4 (0.18%) 4 (0.44%) 2.45 (0.61;9.77) 11 (0.49%) 3 (0.33%) 0.67 (0.19;2.39)
Diseases and disorders of the hepatobiliary system and pancreas 29 (1.52%) 18 (2.38%) 1.57 (0.88;2.80) 85 (4.46%) 25 (3.31%) 0.74 (0.48;1.15) 98 (5.14%) 39 (5.17%) 1.00 (0.70;1.44)
Infectious and parasitic diseases (systemic or unspecified involvement) 25 (2.41%) 15 (4.35%) 1.80 (0.96;3.38) 92 (8.87%) 51 (14.78%) 1.67 (1.21;2.29) * 44 (4.24%) 24 (6.96%) 1.64 (1.01;2.66) *
Skin, subcutaneous tissue, and breast diseases and disorders 4 (0.50%) 4 (1.58%) 3.17 (0.8;12.58) 13 (1.62%) 10 (3.95%) 2.44 (1.08;5.49) * 28 (3.49%) 8 (3.16%) 0.91 (0.42;1.96)
Diseases and disorders of the blood, the haematopoietic system, and the immune system 6 (1.16%) 2 (0.78%) 0.68 (0.14;3.32) 6 (1.16%) 0 (0.00%) - 11 (2.13%) 4 (1.57%) 0.74 (0.24;2.29)
Endocrine, nutritional, and metabolic diseases and disorders 4 (0.82%) 3 (1.29%) 1.57 (0.36;6.98) 7 (1.43%) 7 (3.00%) 2.10 (0.74;5.91) 15 (3.07%) 7 (3.00%) 0.98 (0.40;2.37)
Diseases and disorders of the ear, nose, mouth, and throat 5 (0.99%) 1 (0.71%) 0.71 (0.08;6.06) 13 (2.58%) 5 (3.55%) 1.37 (0.50;3.78) 17 (3.38%) 1 (0.71%) 0.21 (0.03;1.56)
Alcohol/drug use and alcohol/drug-induced organic mental disorders 1 (0.24%) 0 (0.00%) - 0 (0.00%) 0 (0.00%) - 1 (0.24%) 2 (1.48%) 6.09 (0.56;66.62)
Injuries, poisonings, and toxic effects of drugs 2 (0.47%) 3 (1.66%) 3.51 (0.59;20.85) 9 (2.12%) 6 (3.31%) 1.56 (0.56;4.32) 13 (3.07%) 5 (2.76%) 0.90 (0.33;2.49)
Diseases and disorders of the male reproductive system 5 (1.54%) 1 (0.63%) 0.41 (0.05;3.46) 8 (2.47%) 4 (2.52%) 1.02 (0.31;3.33) 16 (4.94%) 6 (3.77%) 0.76 (0.30;1.92)
Myeloproliferative diseases and disorders and poorly differentiated neoplasms 10 (3.27%) 2 (1.85%) 0.57 (0.13;2.55) 34 (11.11%) 17 (15.74%) 1.42 (0.83;2.43) 0 (0.00%) 0 (0.00%) -
Factors influencing health status and other contacts with health services 3 (1.12%) 0 (0.00%) - 8 (2.97%) 1 (0.93%) 0.31 (0.04;2.48) 4 (1.49%) 4 (3.74%) 2.51 (0.64;9.87)
Others ** 35 (6.06%) 10 (5.26%) 0.87 (0.44;1.72) 49 (8.48%) 11 (5.79%) 0.68 (0.36;1.29) 15 (2.6%) 4 (2.11%) 0.81 (0.27;2.41)