TABLE 1.
Comparative in vitro activities of telithromycin, levofloxacin, and other antimicrobial agents against human mycoplasmas
| Organism (no. of strains tested) and antimicrobial agent | MIC (μg/ml)
|
Organism (no. of strains tested) and antimicrobial agent | MIC (μg/ml)
|
|||||
|---|---|---|---|---|---|---|---|---|
| Range | 50% | 90% | Range | 50% | 90% | |||
| M. pneumoniae (25) | ||||||||
| Telithromycin | ≤0.015 | ≤0.015 | ≤0.015 | |||||
| Erythromycin A | ≤0.015 | ≤0.015 | ≤0.015 | |||||
| Roxithromycin | ≤0.015–0.03 | ≤0.015 | ≤0.015 | |||||
| Dirithromycin | ≤0.015–0.06 | ≤0.015 | 0.06 | |||||
| Clarithromycin | ≤0.015 | ≤0.015 | ≤0.015 | |||||
| Azithromycin | ≤0.015 | ≤0.015 | ≤0.015 | |||||
| Josamycin | ≤0.015–0.03 | ≤0.015 | 0.03 | |||||
| Spiramycin | ≤0.015–0.25 | 0.06 | 0.25 | |||||
| Levofloxacin | 0.5–1 | 0.5 | 1 | |||||
| Ofloxacin | 1 | 1 | 1 | |||||
| Doxycycline | 0.06–0.25 | 0.12 | 0.25 | |||||
| M. genitalium (5) | ||||||||
| Telithromycin | ≤0.015 | —a | — | |||||
| Erythromycin A | ≤0.015 | — | — | |||||
| Roxithromycin | ≤0.015 | — | — | |||||
| Dirithromycin | ≤0.015–0.12 | — | — | |||||
| Clarithromycin | ≤0.015–0.06 | — | — | |||||
| Azithromycin | ≤0.015–0.03 | — | — | |||||
| Josamycin | 0.015–0.03 | — | — | |||||
| Spiramycin | 0.12–1 | — | — | |||||
| Levofloxacin | 0.5–1 | — | — | |||||
| Ofloxacin | 1 | — | — | |||||
| Doxycycline | 0.06–0.12 | — | — | |||||
| M. hominis (30)b | ||||||||
| Telithromycin | 2–16 | 16 | 16 | |||||
| Erythromycin A | >64 | >64 | >64 | |||||
| Roxithromycin | >64 | >64 | >64 | |||||
| Dirithromycin | >64 | >64 | >64 | |||||
| Clarithromycin | >64 | >64 | >64 | |||||
| Azithromycin | 32–>64 | 64 | >64 | |||||
| Josamycin | 0.06–0.25 | 0.25 | 0.25 | |||||
| Spiramycin | 32–>64 | >64 | >64 | |||||
| Levofloxacin | 0.12–0.5 | 0.25 | 0.25 | |||||
| Ofloxacin | 0.25–1 | 0.25 | 0.5 | |||||
| Doxycycline | 0.03–16 | 0.06 | 16 | |||||
| M. fermentans (5) | ||||||||
| Telithromycin | 0.06–0.25 | — | — | |||||
| Erythromycin A | 64–>64 | — | — | |||||
| Roxithromycin | 32–64 | — | — | |||||
| Dirithromycin | 64–>64 | — | — | |||||
| Clarithromycin | 16–32 | — | — | |||||
| Azithromycin | 2–8 | — | — | |||||
| Josamycin | 0.12–0.5 | — | — |
| Spiramycin | 2–4 | — | — |
| Levofloxacin | 0.06 | — | — |
| Ofloxacin | 0.12 | — | — |
| Doxycycline | 0.06 | — | — |
| M. penetrans (2) | |||
| Telithromycin | 0.12 | — | — |
| Erythromycin A | 2 | — | — |
| Roxithromycin | 0.5 | — | — |
| Dirithromycin | 16 | — | — |
| Clarithromycin | 0.12 | — | — |
| Azithromycin | 0.12–0.5 | — | — |
| Josamycin | 0.12–0.25 | — | — |
| Spiramycin | 16 | — | — |
| Levofloxacin | 0.06 | — | — |
| Ofloxacin | 0.12 | — | — |
| Doxycycline | 0.12–0.25 | — | — |
| U. urealyticum (doxycycline susceptible) (15) | |||
| Telithromycin | ≤0.015–0.06 | 0.03 | 0.03 |
| Erythromycin A | 0.12–1 | 0.25 | 0.5 |
| Roxithromycin | 0.06–0.5 | 0.25 | 0.25 |
| Dirithromycin | 0.25–2 | 1 | 2 |
| Clarithromycin | ≤0.015–0.03 | 0.03 | 0.03 |
| Azithromycin | 0.06–0.25 | 0.25 | 0.25 |
| Josamycin | 0.03–0.12 | 0.06 | 0.12 |
| Spiramycin | 4–32 | 16 | 32 |
| Levofloxacin | 0.5–1 | 0.5 | 0.5 |
| Ofloxacin | 1–2 | 1 | 2 |
| Doxycycline | 0.06–0.5 | 0.12 | 0.25 |
| U. urealyticum (doxycycline resistant) (15) | |||
| Telithromycin | ≤0.015–0.06 | 0.03 | 0.06 |
| Erythromycin A | 0.12–1 | 0.5 | 1 |
| Roxithromycin | 0.06–0.5 | 0.25 | 0.25 |
| Dirithromycin | 0.25–8 | 1 | 2 |
| Clarithromycin | ≤0.015–0.06 | 0.03 | 0.03 |
| Azithromycin | 0.12–0.5 | 0.25 | 0.25 |
| Josamycin | 0.03–0.12 | 0.12 | 0.12 |
| Spiramycin | 8–32 | 32 | 32 |
| Levofloxacin | 0.5–1 | 1 | 1 |
| Ofloxacin | 1–2 | 1 | 2 |
| Doxycycline | 16–32 | 32 | 32 |
a
—, not determined.
b
The two josamycin-resistant isolates are not included.