Table 2.
Detailed descriptive statistics for mRNA gene expression (2−∆CT) by study group.
| Gene | Study Group | Statistical Parameter * | |||||||
|---|---|---|---|---|---|---|---|---|---|
| M | Trim. M | Me | Q1–Q3 (IQR) | SD | SE | 95% CI | Min.–Max. | ||
| JAK1 | Test group | 0.349 | 0.348 | 0.321 | 0.279–0.389 (0.110) | 0.107 | 0.008 | 0.334–0.365 | 0.058–0.738 |
| Control group | 0.354 | 0.354 | 0.351 | 0.296–0.425 (0.129) | 0.090 | 0.009 | 0.336–0.372 | 0.131–0.628 | |
| Overall | 0.351 | 0.350 | 0.329 | 0.282–0.422 (0.140) | 0.102 | 0.006 | 0.339–0.363 | 0.058–0.738 | |
| JAK2 | Test group | 0.281 | 0.278 | 0.238 | 0.21–0.354 (0.142) | 0.093 | 0.007 | 0.268–0.295 | 0.163–0.707 |
| Control group | 0.262 | 0.260 | 0.247 | 0.201–0.313 (0.112) | 0.070 | 0.007 | 0.248–0.276 | 0.157–0.435 | |
| Overall | 0.274 | 0.271 | 0.238 | 0.211–0.336 (0.125) | 0.086 | 0.005 | 0.264–0.284 | 0.157–0.707 | |
| JAK3 | Test group | 0.413 | 0.409 | 0.391 | 0.273–0.538 (0.265) | 0.164 | 0.012 | 0.389–0.436 | 0.149–0.858 |
| Control group | 0.306 | 0.307 | 0.312 | 0.236–0.376 (0.140) | 0.085 | 0.008 | 0.289–0.323 | 0.112–0.452 | |
| Overall | 0.376 | 0.371 | 0.333 | 0.261–0.488 (0.227) | 0.150 | 0.009 | 0.358–0.393 | 0.112–0.858 | |
| STAT1 | Test group | 0.444 | 0.441 | 0.416 | 0.315–0.578 (0.263) | 0.160 | 0.012 | 0.421–0.467 | 0.205–0.907 |
| Control group | 0.509 | 0.511 | 0.520 | 0.450–0.577 (0.127) | 0.100 | 0.010 | 0.489–0.528 | 0.233–0.705 | |
| Overall | 0.466 | 0.464 | 0.476 | 0.331–0.578 (0.247) | 0.145 | 0.008 | 0.449–0.483 | 0.205–0.907 | |
| STAT2 | Test group | 0.101 | 0.098 | 0.096 | 0.079–0.119 (0.040) | 0.049 | 0.003 | 0.094–0.108 | 0.052–0.685 |
| Control group | 0.116 | 0.103 | 0.099 | 0.084–0.120 (0.036) | 0.110 | 0.011 | 0.094–0.137 | 0.010–0.915 | |
| Overall | 0.106 | 0.099 | 0.096 | 0.081–0.120 (0.039) | 0.076 | 0.004 | 0.097–0.115 | 0.010–0.915 | |
| STAT3 | Test group | 0.413 | 0.410 | 0.334 | 0.276–0.562 (0.286) | 0.175 | 0.013 | 0.388–0.438 | 0.180–0.817 |
| Control group | 0.548 | 0.549 | 0.548 | 0.483–0.619 (0.136) | 0.100 | 0.010 | 0.529–0.569 | 0.307–0.786 | |
| Overall | 0.460 | 0.459 | 0.473 | 0.293–0.587 (0.294) | 0.166 | 0.010 | 0.441–0.479 | 0.180–0.817 | |
| STAT4 | Test group | 0.196 | 0.196 | 0.188 | 0.154–0.242 (0.088) | 0.052 | 0.004 | 0.188–0.203 | 0.099–0.296 |
| Control group | 0.195 | 0.196 | 0.192 | 0.152–0.236 (0.084) | 0.063 | 0.006 | 0.182–0.207 | 0.019–0.324 | |
| Overall | 0.196 | 0.196 | 0.189 | 0.153–0.242 (0.089) | 0.056 | 0.003 | 0.189–0.202 | 0.019–0.324 | |
| STAT5 | Test group | 0.154 | 0.147 | 0.153 | 0.098–0.189 (0.091) | 0.096 | 0.007 | 0.140–0.168 | 0.039–0.948 |
| Control group | 0.489 | 0.490 | 0.495 | 0.412–0.561 (0.149) | 0.110 | 0.011 | 0.467–0.511 | 0.238–0.718 | |
| Overall | 0.269 | 0.263 | 0.191 | 0.135–0.437 (0.302) | 0.189 | 0.011 | 0.248–0.291 | 0.039–0.948 | |
* Explanations of abbreviations used in result tables: M—mean; Trim. M—trimmed mean; Me—median; Q—quartile; Q1—first quartile; Q3—third quartile; IQR—interquartile range; SD—standard deviation; SE—standard error; CI—confidence interval; Min—minimum; Max—maximum. Statistical significance of differences by study groups: JAK1 p = 0.1184; JAK2 p = 0.4433; JAK3 p < 0.0001; STAT1 p < 0.0001; STAT2 p = 0.2034; STAT3 p < 0.0001; STAT4 p = 0.3728; STAT5 p < 0.0001. Values in bold indicate significant difference. All empirical data, considering the gene expression, were log transformed before testing the hypothesis. All the models fitted were controlled for age and gender. Genes: JAK—Janus kina 1–3 s; STAT—signal transducer and activator of transcription protein 1–5.