Table 4.

Subgroup meta-analyses on the use of collagen as a scaffold.

	Number of Cohorts	Number of Patients	Proportion or SMD	95% Confidence Interval	95% Prediction Interval	psubgroup
Integration
Complete Integration
Collagen Scaffold	4	69	0.7263	0.5361, 0.8591	0.4630, 0.8909	0.0616
Other techniques	8	154	0.5590	0.3859, 0.7189	0.1801, 0.8797
Clinical Scores
IKDC
Collagen Scaffold	2	100	1.9780	1.0121, 2.9439	N/A	0.0047
Other techniques	8	169	1.4283	1.0051, 1.8516	0.3801, 2.4766
KOOS Pain
Collagen Scaffold	7	174	6.3287	4.1189, 8.5385	0.2874, 12.3700	0.0064
Other techniques	2	50	2.4036	−11.8279, 16.6351	N/A
KOOS Symptoms
Collagen Scaffold	7	174	5.5559	3.3265, 7.7854	−0.6257, 11.7376	0.0579
Other techniques	2	50	2.1616	−17.4148, 21.7380	N/A
Lysholm
Collagen Scaffold	2	57	3.6742	−12.6766, 20.0249	N/A	0.2645
Other techniques	5	54	1.8202	−1.0972, 4.7377	−6.1101 9.7506
TAS
Collagen Scaffold	4	71	3.2418	0.5963, 5.8872	−4.0359, 10.5194	0.0090
Other techniques	5	99	0.8512	−0.2112, 1.9135	−1.7837, 3.4860
SF-36 Physical
Collagen Scaffold	5	101	4.7544	1.9547, 7.5541	−2.7818, 12.2906	0.0004
Other techniques	2	16	1.1053	−1.7924, 4.0030	N/A
SF-36 Mental
Collagen Scaffold	5	101	2.2829	1.0191, 3.5467	−0.9880, 5.5538	<0.0001
Other techniques	2	16	−0.5795	−3.3890, 2.2300	N/A
Graft Failure
Collagen Scaffold	8	282	0.0657	0.0442, 0.0965	0.0436, 0.0977	0.3449
Other techniques	4	61	0.0904	0.0345, 0.2162	0.0179, 0.3513