Figure 1.

CRP kinetics, Horovitz Quotient and SOFA scores of all patients of the case series. CRP was measured at least every 24 h in all patients during in-hospital stay. Red lines indicate 10 mg/L and 100 mg/L as reference for normal levels and cut-off for severe COVID-19 progression respectively. Blue line indicates 300 mmHg as cut-off for an acute lung injury measured by the Horovitz Quotient. Grey bars indicate apheresis treatments. Ventilation by High Flow or Non-Invasive Ventilation (NIV) is marked in yellow. Mechanical ventilation is marked in orange and extracorporeal membrane oxygenation (ECMO) is marked with purple stripes. No ventilation and nasal cannula are not indicated (for details see Table 1). SOFA scores are displayed at corresponding timepoints. For patient 6 the SOFA score was only determined once.