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. 2022 Apr 2;23(7):3965. doi: 10.3390/ijms23073965

Figure 3.

Figure 3

Comparison of inflammatory, oxidative stress and lipid markers between BTBR WT (left) and BTBR ob/ob (right) at 12 weeks. (A) Representative image of pSTAT3 (long arrow) immunostaining (magnification 200×) and (B) pSTAT3 activation quantification. (C) pNRF2 staining (dotted arrow) as oxidative stress response (magnification 100×) and area quantification (D). (E) 4-HNE staining (short arrow) as lipoperoxidation (magnification 100×) and its quantification (F). In the lower row (G) is shown mRNA expression of several inflammation (Tnfα, Ifnγ, Il-12, Ccl2 and Ccl5); oxidative stress (Nrf2, Hmox-1, Sod-1 and Catalase) and lipid uptake/efflux (CD36, CD204, ABCa1 and ABCg1) genes. Data are shown as scatter dot plots and mean ± SEM of each group (n = 5 mice/group); * p < 0.05, ** p < 0.01, vs. BTBR WT.