Table 1.
Metabolic and biochemical parameters in BTBR WT and BTBR ob/ob at 12 w. Data are shown as Median (IQR). ** p < 0.01; *** p < 0.001 vs. BTBR WT. Abbreviations: AST: aspartate aminotransferase; ALT: alanine aminotransferase; AP: Alkaline Phosphatase; HDL-C: high-density lipoprotein cholesterol LDL-C: low-density lipoprotein cholesterol. & Undetectable. % n-fold change vs. BTBR WT.
| Variables | BTBR WT | BTBR ob/ob | n-Fold Change % |
|---|---|---|---|
| AST (IU/L) | 46 (39.75, 50.75) | 76 (66.5, 58) ** | 1.65 |
| ALT (IU/L) | 27 (23, 30.25) | 62 (52, 72.5) *** | 2.29 |
| AST/ALT ratio | 1.66 (1.39, 2.16) | 1.09 (1.02, 1.46) | - |
| AP (IU/L) | 60.5 (54.75, 84.25) | 146 (123.5, 163.5) *** | 2.41 |
| Total Cholesterol (mg/dL) | 118 (103.3, 126.8) | 215 (181, 275) ** | 1.82 |
| Triglycerides (mg/dL) | 123.5 (99.25, 129) | 253.5 (192, 310.5) ** | 2.05 |
| HDL (mg/dL) | 101 (89.75, 109.3) | 149 (141, 198) ** | 1.48 |
| LDL (mg/dL) | 0 (0, 0) & | 19 (4, 26,5) | - |