Table 2.
Metabolic and biochemical parameters in BTBR WT, BTBR-STZ and BTBR ob/ob at 22 weeks. Data are shown as Median (IQR). * p < 0.05; ** p < 0.01; *** p < 0.001 vs. BTBR WT § non-parametric data: Mann-Whitney U test. Abbreviations: LW/BW: Liver weight/body weight ratio; AST: aspartate aminotransferase; ALT: alanine aminotransferase; AP: Alkaline Phosphatase; HDL-C: high-density lipoprotein cholesterol LDL-C: low-density lipoprotein cholesterol. & Undetectable. % n-fold change BTBR ob/ob vs. BTBR WT.
| Variables | BTBR WT | BTBR STZ | BTBR ob/ob | n-Fold Change % |
|---|---|---|---|---|
| Water intake (mL/day) | 5 (5, 6) | - | 38 (32, 45) ***, § | 7.60 |
| Food intake (g/day) | 6.7 (6.3, 7.8) | - | 13.12 (12.17, 14.13) ***, § | 1.96 |
| Liver weight (g) | 2.70 (2.60, 3.20) | - | 6.19 (5.90, 6.82) *** | 2.29 |
| Body weight (g) | 37 (36, 38) | 31 (30, 34) ***, § | 71 (69, 72) *** | 1.91 |
| LW/BW ratio | 2.7 (2.5 3.2) | - | 6.2 (5.9 6.9) * | 2.30 |
| Glycemia 22 week (mg/dL) | 152 (149, 157) | 350 (265, 380) ***, § | 525 (493, 569) *** | 3.45 |
| AST (IU/L) | 80 (64, 134) | 88 (83, 95) | 84 (74, 116) § | 1.05 |
| ALT (IU/L) | 14 (11, 30) | 38 (35, 42) | 40 (35, 52) **, § | 2.86 |
| AST/ALT ratio | 5.3 (3.9, 6.9) | 2.0 (2.5 2.7) | 2.0 (1.7, 2.7) *** | - |
| AP (IU/L) | 38 (34, 54) | 127 (108, 141) | 97 (74, 113) *** | 2.55 |
| Total Cholesterol (mg/dL) | 128 (121, 142) | 112 (104, 120) **, § | 204 (166, 233) *** | 1.59 |
| Triglycerides (mg/dL) | 56 (53, 73) | 134 (110, 151) | 108 (98, 136) *** | 1.93 |
| HDL (mg/dL) | 102 (98, 108) | 96 (88, 103) **, § | 158 (122, 175) *** | 1.55 |
| LDL (mg/dL) | 10 (7, 27) | 0 (0, 0) & | 29 (24, 38) *, § | 2.90 |