Table 4.

Prespecified subgroup analyses.

	Intervention	Control	HR	CI 95	p
Overall	47/75	58/75	0.67	0.46–0.99	0.046
Sex
Female	20/37	33/38	0.44	0.25–0.78	0.005
Male	27/38	25/37	1.02	0.59–1.76	0.94
Left ventricular ejection fraction
Preserved	25/47	40/46	0.41	0.24–0.67	<0.001
Reduced	19/23	18/29	1.59	0.83–3.04	0.16
Frailty
Yes	24/39	31/39	0.70	0.41–1.19	0.19
No	23/35	26/35	0.70	0.40–1.24	0.22
Previous HF diagnosis
Yes	17/32	25/33	0.49	0.26–0.92	0.026
No	30/43	33/42	0.81	0.49.1.33	0.41
HF hospitalization in ≤12 months
Yes	16/19	11/15	1.12	0.51–2.45	0.78
No	17/27	17/23	0.70	0.35–1.37	0.30