Table 6.

Reported RSV results in bone regeneration.

Ref.	Authors (Year)	Type of the Study/Days	Aim of the Study	Materials	Results
[276]	Zhang et.al 2020	Research in vitro	If RSV with or without SrRn has differentiating power on the MSC; If RSV with or without SrRn inhibits the action of osteoclasts; If RSV with or without SrRn induces angiogenesis If in rats rehabilitated with 3D scaffolds with RSV associated or not with SrRn, there is bone formation	− Scaffold only − Scaffold with SrRn − Scaffold with RSV − Scaffold with RSV and SrRn	MSC proliferation in scaffolds with SrRn is greater than other groups; Action of osteoclasts is inhibited in scaffolds with RSV, SrRn and both; Angiogenic effect is greatest in scaffolds with RSV; High bone formation in mandible with scaffolds with RVS and SrRn compared to the other two groups.
[95]	Borsani et.al 2018	Research in vitro	The researchers wanted to see how CGFs and/or resveratrol affected the proliferation and differentiation of human osteoblasts, whether they were treated with bisphosphonates or not.	Osteoblast growth medium (OGM): control group OGM + RSV 10 µM OGM + AL 5 µM OGM + ZOL 5 µM OGM + AL 5 µM +RSV 10 µM OGM + ZOL 5 µM +RSV 10 µM OGM + CGF OGM + CGF + RSV 10 µM OGM + CGF + AL 5 µM OGM + CGF + ZOL 5 µM OGM + CGF + RSV 10 µM + AL 5 µM OGM + CGF + RSV 10 µM + ZOL 5 µM	CGF and RSV both have an osteogenic impact and protect ZOL-treated osteoblasts; In osteoblasts treated with RSV + ZOL or CGF + RSV + ZOL, OPG levels are higher; BMP-2 levels rose sharply in osteoblasts treated with CGF + RSV + AL or CGF + RSV + ZOL, but not as much as in osteoblasts treated with CGF + ZOL; There is a rise in SIRT-1 and Col 1 in osteoblastic cells treated with RSV + CGF + ZOL; Human osteoblastic cells treated with RSV deposited substantial amounts of calcium.