TABLE 1.
MICs determined by the BACTEC method for M. avium 101 grown within Acanthamoeba
| Antibiotic | MIC typea | MIC (μg/ml) for M. avium culture
|
||
|---|---|---|---|---|
| Cultured in amoebae (day 1) and passaged on 7H11 | Cultured in amoebae (day 4) and passaged on 7H11 | Control (7H11 culture) | ||
| Azithromycin | MIC99 | 39 | 41 | 26b |
| MIC99.9 | 52 | 67 | 49b | |
| Clarithromycin | MIC99 | 3.3 | 3.6 | 1.9b |
| MIC99.9 | 4.9 | 5.1 | 3.0b | |
| Rifabutin | MIC99 | 0.6 | 0.5 | 0.5b |
| MIC99.9 | 0.8 | 0.6 | 0.6b | |
a
MIC99, MIC at which 99% of the isolates tested are inhibited; MIC99.9, MIC at which 99.9% of the isolates tested are inhibited. The data represent the numbers obtained in a representative experiment (BACTEC assay was carried out twice). The numbers were obtained by using the T100 method as previously described (4).
b
P > 0.05 compared with the MICs of antibiotics against M. avium grown in amoebae and passaged on 7H11 medium.