Table 1.
Demographic characteristics of the study patients. P values are determined by Mann-Whitney U test.
| Group | Young (<38 y/o) n = 60 |
Advanced (≥38 y/o) n = 50 |
p Value |
|---|---|---|---|
| Age (year) | 33.5 ± 3.1 | 40.7 ± 1.9 | <0.001 |
| AMH (ng/mL) | 5.04 ± 3.59 | 3.19 ± 3.03 | 0.001 |
| BMI (kg/m2) | 23.0 ± 4.7 | 23.1 ± 3.4 | 0.501 |
| Baseline FSH (IU/L) | 6.63 ± 3.04 | 7.76 ± 4.12 | 0.144 |
| Baseline LH (IU/L) | 6.01 ± 4.68 | 8.06 ± 12.92 | 0.746 |
| Baseline E2 (pg/mL) | 46.3 ± 34.8 | 46.8 ± 41.9 | 0.696 |
| Number of oocytes retrieved | 16.0 ± 11.9 | 11.2 ± 6.4 | 0.017 |
| Number of metaphase II oocytes | 12.8 ± 9.8 | 9.1 ± 5.7 | 0.048 |
| Number of 2 pronuclei (2PN) | 10.0 ± 8.6 | 6.7 ± 4.3 | 0.057 |
| Fertilization rate | 74.3 ± 24.3 | 76.2 ± 22.6 | 0.653 |
| D3 good quality embryo number | 7.2 ± 6.0 | 4.9 ± 3.5 | 0.031 |
| D5 good blastocyst number | 4.4 ± 3.2 (n = 51) |
3.3 ± 2.7 (n = 43) |
0.044 |
| Aneuploidy number | 0.9 ± 0.9 (n = 51) |
1.8 ± 1.5 (n = 43) |
0.001 |
| Aneuploidy rate (%) | 23.2 ± 28.6 (n = 51) |
61.1 ± 39.1 (n = 43) |
<0.001 |
| TL in leukocytes | 0.76 ± 0.43 a | 0.66 ± 0.37 b | 0.214 |
| TL in granulosa cells | 0.37 ± 0.16 a | 0.33 ± 0.12 b | 0.094 |
| mtDNA copy number in leukocytes | 143.01 ± 76.5 c | 146.4 ± 89.26 d | 0.83 |
| mtDNA copy number in granulosa cells | 306.47 ± 137.2 c | 288.3 ± 100.85 d | 0.439 |
ap < 0.001; b p < 0.001; c p < 0.001; d p < 0.001.