Head Activator 2 nM |
GPR37 |
Receptor internalization within heterologous cells [29]
Calcium stimulation via Ga16/aequorin assay [29]
Calcium-mediated NFAT transcription [30]
Inhibition of cAMP accumulation [30]
|
Prosaposin/TX14A 100 nM–1 µM |
GPR37 GPR37 L1 |
Receptor internalization within heterologous cells [34]
ERK1/2 phosphorylation [34], GTPγS accumulation [34], inhibition of cAMP within HEK293T cells [34]
ERK1/2 phosphorylation and protection from oxidative stress within primary astrocytes [34]
Macrophage phagocytosis of zymosan particles via calcium signaling [24]
|
Neuroprotection D1 30 nM |
GPR37 |
Increase in intracellular calcium levels within HEK292T cells [24]
Increase in intracellular calcium levels coupled with the active phagocytosis of zymosan particles within peritoneal macrophages [24]
|
Osteocalcin 20 nM |
GPR37 |
Increase in intracellular calcium levels in HEK293-GCamP6s cells [41]
β-arrestin recruitment using a PRESTO-Tango GPCR assay system in HTLA cells [41]
Inhibition of cAMP and stimulation of ERK phosphorylation within HEK293 cells overexpressing GPR37 [41]
|