Skip to main content
. 2022 Apr 5;23(7):4028. doi: 10.3390/ijms23074028

Table 1.

Proposed ligands for GPR37 and GPR37 L1.

Ligand Receptor Mechanisms and Signaling Pathways
Head Activator
2 nM
GPR37
  1. Receptor internalization within heterologous cells [29]

  2. Calcium stimulation via Ga16/aequorin assay [29]

  3. Calcium-mediated NFAT transcription [30]

  4. Inhibition of cAMP accumulation [30]

Prosaposin/TX14A
100 nM–1 µM
GPR37
GPR37 L1
  1. Receptor internalization within heterologous cells [34]

  2. ERK1/2 phosphorylation [34], GTPγS accumulation [34], inhibition of cAMP within HEK293T cells [34]

  3. ERK1/2 phosphorylation and protection from oxidative stress within primary astrocytes [34]

  4. Macrophage phagocytosis of zymosan particles via calcium signaling [24]

Neuroprotection D1
30 nM
GPR37
  1. Increase in intracellular calcium levels within HEK292T cells [24]

  2. Increase in intracellular calcium levels coupled with the active phagocytosis of zymosan particles within peritoneal macrophages [24]

Osteocalcin
20 nM
GPR37
  1. Increase in intracellular calcium levels in HEK293-GCamP6s cells [41]

  2. β-arrestin recruitment using a PRESTO-Tango GPCR assay system in HTLA cells [41]

  3. Inhibition of cAMP and stimulation of ERK phosphorylation within HEK293 cells overexpressing GPR37 [41]