Table 3.

Different Brain on a chip models and their applications.

Models	Applications	References
Microfluidic models	Study of tight junctions, and BBB functions	[61]
Compartmentalized models	Study of diseases development and behavior associated with neural networks	[27, 28, 29]
Hydrogel based models	These models biomimic in-vivo microenvironment. They allow cells to interact, migrate, and propagate in 3D. They also exhibit transport properties that mimic in vivo conditions	[62]
Spheroid models	Disease modeling and drug discovery	[63]