FIG. 1.

(A) Mice were infected with R. oryzae as described in the text and placed into the following treatment groups: untreated controls (■), trovafloxacin treated (▾), fluconazole treated (●), fluconazole plus trovafloxacin treated (▴), or amphotericin B treated (⧫). Significant positive effects on percent survival were seen in mice treated with amphotericin B or the combination of fluconazole plus trovafloxacin. (B) In the same experiment, mice were also treated with amphotericin B plus fluconazole plus trovafloxacin (□) or with amphotericin B plus trovafloxacin (○). The curves for single drug treatment are repeated for purposes of comparison and are the same as those depicted in Fig. 1A. The addition of one or two other drugs to amphotericin B resulted in no additional survival benefit or antagonism of amphotericin B.