Effect of ciprofloxacin in combination therapy with fluconazole and quinolones. Mice were treated as in previous experiments, with the exception that ciprofloxacin was substituted for trovafloxacin. The treatment groups were as follows: untreated controls (■), ciprofloxacin treated (▾), fluconazole treated (●), fluconazole plus ciprofloxacin treated (▴), and amphotericin B treated (⧫). No differences in survival were noted in mice treated with fluconazole and either trovafloxacin or ciprofloxacin.