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COVID-19 associated multiorgan diseases. ACE2 was found to be expressed in the lungs, the main entry route, as well as several tissues (including vessel endothelial and smooth muscle) and other vital organs (brain, heart, kidney, intestine, liver, etc.). Pulmonary and extrapulmonary manifestations are marked in SARS-CoV-2 infection and are summarized in this figure. Organ dysfunction includes both direct SARS-CoV-2 cytotoxic effects and cytokine-mediated damage.
