Table 3.
Drug-induced AMES toxicity, hERG (I) inhibition, carcinogens, rat acute toxicity (LD50 in mol/kg), tetrahymena pyriformis (TP) toxicity, and skin sensitization activity of the four selected compounds. (NC indicates non-carcinogenic).
| Parameters | Compounds | |||
|---|---|---|---|---|
| CID: 102004710 | CID: 198912 | CID: 11969465 | CID: 5281349 | |
| Ames toxicity | No | Yes | No | Yes |
| hERG I inhibition | No | No | No | No |
| Carcinogens | NC | NC | NC | NC |
| Rat acute toxicity | 2.853 | 2.82 | 2.665 | 2.973 |
| TP toxicity | 0.316 | 0.433 | 0.352 | 0.888 |
| HB toxicity | No | Yes | Yes | No |
| Fish toxicity | No | No | Yes | Yes |
| Skin sensitization | No | No | No | Yes |