Table 2.
% Inhibition at 50μΜ and IC50 values of tested compounds for SARS-CoV-2 3CL protease.
| No | R1 | R2 | % Inhibition at 50 μM | IC50 (μΜ) |
|---|---|---|---|---|
| a3 | 4,5-di-Cl | 4-F | 0 | >50 |
| a1 | 7-Cl | 2,6-di-F | 0 | >50 |
| b1 | 6-F | 4-F | 0 | >50 |
| c1 | 6-Cl | 4-F | 88.03 | 4.736 |
| c5 | 6-Cl | 4-OH | 7.87 | >50 |
| d1 | 4-Cl | 4-F | 6.72 | >50 |
| e2 | 4-OCH3 | 4-NO2 | 31.30 | >50 |
| h6 | 6-OCF3 | 4-F | 25.18 | >50 |
| h8 | 6-OCF3 | 4-Cl | 3.04 | >50 |
| k3 | 6-CN | 2-F, 6-Cl | 100 | 0.010 |
| n2 | 4-Me, 6-Ad | 2-F, 6-Cl | 100 | 9.984 |
| m2 | 6-Ad | 2-F, 6-Cl | 2.79 | >50 |
| m11 | 6-Ad | 4-Br | 45.00 | >50 |
| A1 | 6-Ad | 4-NO2 | 94.11 | 34.4 |
| A2 | 6-Ad | 2,6-di-F | 91.34 | 13.21 |
| GC376 | 100 at 100 μM | 0.439 |