TABLE 3.
Proportion of mice infected with Aspergillus with negative lung cultures following prophylactic treatment with SCH 56592
| SCH dose (mg/kg) | Strain | Total no. of micea | % (no.) of mice with negative lung culturesb |
|---|---|---|---|
| 25 | A. fumigatus ND152 | 16 | 75 (12) |
| A. fumigatus ND158 | 8 | 62 (5) | |
| A. flavus ND83 | 16 | 6 (1) | |
| 10 | A. fumigatus ND152 | 16 | 63 (10) |
| A. fumigatus ND158 | 8 | 50 (4) | |
| A. flavus ND83 | 16 | 0 | |
| 5 | A. fumigatus ND152 | 16 | 31 (5) |
| A. fumigatus ND158 | 8 | 50 (4) | |
| A. flavus ND83 | 16 | 6 (1) | |
| 2.5 | A. fumigatus ND152 | 16 | 6 (1) |
| A. fumigatus ND158 | 8 | 0 | |
| A. flavus ND83 | 16 | 0 |
a
The surviving mice were killed, and lung homogenates were diluted and spread onto SDA plates. The totals include the mice from two experiments with strains ND152 and ND83 and one experiment with strain ND158.
b
No growth was detected on SDA plates with a 101 dilution.