TABLE 4.
Efficacies of therapeutic and prophylactic administration of SCH and FLC (both once daily) against systemic C. albicans infections in mice
| C. albicans susceptibility and strain | Mice | PD50 (mg/kg)
|
|||
|---|---|---|---|---|---|
| Therapeutic administration (day 4)a
|
Prophylactic administration (day 7)b
|
||||
| SCH | FLC | SCH | FLC | ||
| FLC S | |||||
| C43 | Normal | 0.3 | 1.2 | NDc | ND |
| C43 | Irradiated | 1.7 | 6.1 | 1.5 | 5.3 |
| C84 | Normal | 0.6 | 4.3 | ND | ND |
| C286 | Normal | 0.1 | 0.9 | ND | ND |
| C65 | Irradiated | 0.04 | 2.6 | ND | ND |
| C72 | Irradiated | 0.6 | 2.4 | ND | ND |
| FLC S-DD | |||||
| C288 | Normal | 0.6 | 25 | ND | ND |
| C288 | Irradiated | ND | ND | 7.8 | >25 |
| C342 | Normal | 7.1 | 30.5 | ND | ND |
| FLC R | |||||
| C284 | Normal | 4.1 | 342 | ND | ND |
| C284 | Irradiated | ND | ND | 7.0 | 431 |
| C260 | Normal | 15.6 | 417 | ND | ND |
| C310 | Irradiated | ND | ND | 19.4 | 204 |
a
PD50 determined on day 4 postinfection.
b
PD50 determined on day 7 postinfection.
c
ND, not done.