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. 2022 Apr 6;12(7):1231. doi: 10.3390/nano12071231

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Detailed network of the 18 articles that met all the eligibility criteria. The dashed rectangle highlights article [41], summarized in Table 3. In short, [41] used MIONs with a size ranging between 10 and 100 nm. MIONs were exposed to a bronchoalveolar lavage fluid (BALF) extracted from mice, inducing an increase of EVs biogenesis. EVs, with a size between 30 and 100 nm and enriched in TSG101, induced iDC maturation, immune-system activation, and T-cell differentiation. Overall, and regarding all experimental conditions, exosome morphology and size were not affected. (B) Most relevant biological outcomes and their connections among the 18 analyzed articles. For instance, despite using different experimental conditions, 15 out of 18 articles pointed to increased EV biogenesis as one of their outcomes. Regarding the duplicated author’s nomenclature, ZhuA, ZhuB, GurunathanA, and GurunathanB correspond to [22,41,44,45], respectively.

(A) Detailed network of the 18 articles that met all the eligibility criteria. The dashed rectangle highlights article [41], summarized in Table 3. In short, [41] used MIONs with a size ranging between 10 and 100 nm. MIONs were exposed to a bronchoalveolar lavage fluid (BALF) extracted from mice, inducing an increase of EVs biogenesis. EVs, with a size between 30 and 100 nm and enriched in TSG101, induced iDC maturation, immune-system activation, and T-cell differentiation. Overall, and regarding all experimental conditions, exosome morphology and size were not affected. (B) Most relevant biological outcomes and their connections among the 18 analyzed articles. For instance, despite using different experimental conditions, 15 out of 18 articles pointed to increased EV biogenesis as one of their outcomes. Regarding the duplicated author’s nomenclature, ZhuA, ZhuB, GurunathanA, and GurunathanB correspond to [22,41,44,45], respectively.