Table 1.
Baseline Clinical Characteristics of Patient with Sepsis-Associated DIC by Comparing Two Causative Organs
| Site of Infection | Biliary Tract | Respiratory Tract |
|---|---|---|
| Patient | n = 62 | n = 84 |
| Age, median (range) | 79 (50–102) | 76 (20–97) |
| Sex, male, n (%) | 31 (50) | 49 (58) |
| APACHE-II score, mean (SD) | 15 (5.3) | 21 (6.5) |
| JAAM DIC score, mean (SD) | 5.9 (1.2) | 5.6 (1.2) |
| Clinical diagnosis (n) | Acute cholangitis (45) Acute cholecystitis (12) Liver abscess (5) |
Acute pneumonia (34) Aspiration pneumonia (18) ARDS (15) Interstitial pneumonia (7) Drug-induced pneumonia (1) Irradiation pneumonia (1) |
| Anti-DIC treatment, n (%) | ||
| rTM | 45 (73) | 59 (70) |
| AT | 10 (16) | 17 (20) |
| rTM + AT | 7 (11) | 8 (10) |
| Intravenous immunoglobulin, n (%) | 15 (24) | 31 (37) |
| PMX-HP, n (%) | 4 (6.5) | 13 (15) |
| Mechanical ventilation, n (%) | 7 (11) | 47 (56) |
| Biliary drainage, n (%) | 41 (66) | 0 (0) |
| Improvement of DIC, n (%) | 41 (66) | 38 (45) |
| 30-day OS (%) | 56.5 | 39.3 |
Abbreviations: APACHE-II, Acute Physiology and Chronic Health Evaluation II; JAAM, Japanese Association for Acute Medicine; DIC, disseminated intravascular coagulation; rTM, recombinant thrombomodulin, AT; antithrombin, PMX-HP, Polymyxin B hemoperfusion; OS; overall survival; ARDS, acute respiratory distress syndrome.