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(a) Berberine (BER) plasma concentration at different times (0–8 h) on Day 1 and over the course of the BER-β-glycerophosphate (BER-GP) cream topical treatment in non-infected (filled circles) and L. major-infected mice (open squares), measured in blood extracted 12 h after the last daily administration (Ctrough). (b) Skin BER levels at different times (0–12 h) on Day 1, Day 10 (D10) and Day 35 (D35), 12 h after the last treatment. Results are expressed as mean ± SD (n = 2–4).
