Table 2.
Stability studies for berberine-β-glycerophosphate (BER-GP) cream over a period of 8 months at different storage temperatures
| BER-GP cream | 3 months | 8 months | ||||
|---|---|---|---|---|---|---|
| 4°C | 25°C | 40°C | 4°C | 25°C | 40°C | |
| pH | 4.70 ± 0.35 | 3.79 ± 0.30 | 4.13 ± 0.16 | 3.71 ± 0.12 | 3.67 ± 0.20 | 3.86 ± 0.25 |
| Spreadability (cm) | 0.60 ± 0.07 | 0.50 ± 0.04 | 0.70 ± 0.14 | 0.65 ± 0.15 | 0.70 ± 0.14 | 0.85 ± 0.08 |
| BER recovery (%) | 99.5 ± 2.1 | 98.2 ± 1.8 | 98.2 ± 1.8 | 100.5 ± 2.2 | 79.2 ± 1.8 | 73.2 ± 6.2 |
| Colour | Intense yellow | Intense yellow | Intense yellow | Intense yellow | Pale yellow | Pale yellow |
| Other organoleptic properties | Smooth, soft, characteristic MNT odour | Smooth, soft, characteristic MNT odour | ||||
| Phase separation | No evidence | No evidence | No evidence | No evidence | Yes | Yes |
| Drug precipitation | No evidence | No evidence | No evidence | No evidence | No evidence | No evidence |
| Gravitational stability | Yes | Yes | Yes | Yes | Yes | Yes |
Data expressed as mean ± SD (n = 3).