. Author manuscript; available in PMC: 2022 Apr 11.

Published in final edited form as: J Proteome Res. 2021 Mar 11;20(4):2116–2121. doi: 10.1021/acs.jproteome.0c00963

Table 1.

Enrichment Methods in leapR

enrichment method	application
enrichment_comparison	Is pathway abundance different between the case and control?
enrichment_in_sets	Are pathway members over-represented in a subset?
enrichment_in_order	Are pathway members grouped in an ordered list?
correlation_enrichment	Are pathway members significantly correlated with each other?
enrichment_in_pathway	Is the pathway more abundant than the background?
enrichment_in_relationships	Are pathway members enriched in relationships (e.g., PPIs?)