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. 2022 Mar 28;13:815301. doi: 10.3389/fphys.2022.815301

FIGURE 5.

FIGURE 5

mRNA expression of ion channels and related regulatory proteins in normal, EAM, and Ro-32-0432-treated EAM rat hearts. (A–G) Relative mRNA expressions of Nav1.5, Kv4.2, Cav1.2, RYR, NCX, KchIP2, and SERCA2a. mRNA expressions of Kv4.2 and Cav1.2 were significantly increased in EAM rats, whereas Ro-32-0432 treatment did not have a significant reduction or even a slight increase (Cav1.2) compared with EAM rats. mRNA expressions of KchIP and SERCA2a had no difference in the hearts of normal, EAM, and Ro-32-0432-treated EAM rat. (H–J) mRNA expressions of Kv4.2, SERCA2a, and KchIP2 in the left ventricular wall. Error bars represent mean ± SD, n = 5 for each group. *p < 0.05 vs. control; ***p < 0.001 vs. control; #p < 0.05 vs. EAM.