FIGURE 1.
Conditional deletion of p120 in keratinocytes of p120cKO mice. Four-month-old p120cKO mice, with the deletion in keratinocytes being initiated by tamoxifen administration at four-week-old, were examined while p120-floxed littermates lacking the Cre were used as controls. After tamoxifen injection, sections of epidermal tissue from both groups were processed for H&E histochemistry and immunohistochemical staining with antibodies against p120 or K14. PCR and western analysis of p120 in keratinocytes were also performed. (a) A representative field of epidermal sections immunostained with p120 and K14 antibodies. (b and c) Quantitation of p120 mRNA and protein isolated from the epidermis. (d) The specificity of p120 deletion verified by PCR analysis of the epidermis and other tissues. *p < 0.05. Error bars: mean ± SD